Science Review: Autoimmune and inflammatory Thyroid Diseases Following Vaccination with SARS-CoV-2 Vaccines

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Phillipe Caron published a short review in 2022 on thyroid disease exacerbated in patients who have received the covid-19 vaccination.

If thyroid markers on routine bloodwork are abruptly out of range, this could be one contributing culprit.

In my weight loss resistant clients, I focus primarily on identifying and removing the worst offenders contributing to inflammation in the body, which often slows weight loss. We know that high levels of inflammation affect thyroid function.

Since normal metabolism itself creates inflammation-inducing free radicals as a byproduct of energy production, when systemic levels of  inflammation in the body are high due to external causes, the thyroid will wisely slow the rate of metabolism to literally slow the fire of inflammation.

The following review published in 2022 highlights one of these external worst offenders driving inflammation and it’s affect on thyroid function:

Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management

Key Points:

A massive vaccination campaign using several types of vaccines against SARS-CoV-2 has been undertaken around the world with benefits to morbidity and mortality, but an increasing number of autoimmune and inflammatory-related side effects are described (thrombotic thrombocytopenia, Guillain Barré syndrome, myocarditis/pericarditis, type 1 diabetes mellitus, premature ovarian failure, adrenal insufficiency)

In patients with autoimmune thyroiditis, the appearance of an episode of thyrotoxicosis within a few days of the first dose of vaccination may suggest that the patient had a (chronic) autoimmune thyroiditis which was aggravated by the SARS-CoV-2 vaccines, or that thyroid dysfunction may be mild or moderate, and consequently this diagnosis of painless or autoimmune thyroiditis may be overlooked.

SARS-CoV-2 vaccination may induce autoimmune and inflammatory thyroid dysfunctions, and may precipitate different forms of thyrotoxicosis (autoimmune hyperthyroidism or Graves’ disease, overt subacute thyroiditis and atypical autoimmune thyroiditis, or concurrence of subacute thyroiditis and Graves’ disease).

Genetic predisposition or susceptibility: despite a mass immunization campaign against Covid-19 infection, thyroid adverse effects such as subacute thyroiditis, Graves’ disease and silent autoimmune thyroiditis appear to be rare, suggesting they are probably under-reported adverse effects of Covid-19 vaccines or are usually occurring with individual predisposition or genetic susceptibility.

Reference:

Caron P. Autoimmune and inflammatory thyroid diseases following vaccination with SARS-CoV-2 vaccines: from etiopathogenesis to clinical management. Endocrine. 2022 Dec;78(3):406-417. doi: 10.1007/s12020-022-03118-4. Epub 2022 Jun 28. PMID: 35763241; PMCID: PMC9243876. Free Full Text.

Further reading:

İremli BG, Şendur SN, Ünlütürk U. Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome. J Clin Endocrinol Metab. 2021 Aug 18;106(9):2600-2605. doi: 10.1210/clinem/dgab373. PMID: 34043800; PMCID: PMC8194612.

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